Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
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چکیده
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the role of thematic structure in comprehending spoken language
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15 صفحه اولDeficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy.
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Structure of a site-2 protease family intramembrane metalloprotease.
Regulated intramembrane proteolysis by members of the site-2 protease (S2P) family is an important signaling mechanism conserved from bacteria to humans. Here we report the crystal structure of the transmembrane core domain of an S2P metalloprotease from Methanocaldococcus jannaschii. The protease consists of six transmembrane segments, with the catalytic zinc atom coordinated by two histidine ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07864-w